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Tony Cass


Tony is Professor of Chemical Biology in the Department of Chemistry and the Institute of Biomedical Engineering at Imperial College London. After graduating with degrees in Chemistry from the Universities of York and Oxford and a period as a Research Fellow in Oxford, he moved to Imperial College London. He is a Fellow of both the Royal Society of Chemistry and the Royal Society of Biology as well as a member of the Institute of Engineering and Technology and the American Chemical Society.

During his early career he pioneered the use of synthetic electron transfer mediators in enzyme electrodes, which led to the first electronic blood glucose sensors used by millions of diabetes patients and generating revenues in excess of $10 bn per year. Tony also published some of the first papers on using protein engineering to enhance biosensor performance and started an extremely fruitful collaboration in this area with Prof Xian-En Zhang (Chinese Academy of Sciences).

His current research is focused on using analytical science to solve problems in animal, environmental and human health especially through creating devices that perform the analysis at point of decision in the belief that providing measurement data rapidly can allow remedial action to be taken much more effectively. Current projects include continuous glucose monitoring with microneedle devices for diabetes management, early detection of bile salts in maternal blood for diagnosis of cholestasis of pregnancy, pen side avian influenza diagnostics, and determination of arsenic(III) in drinking water. To realise these devices his research uses a combination of biomolecular engineering of proteins and nucleic acids, low cost production of electrochemical sensors and performance enhancement through the use of nanomaterials. T

His work has been recognised by the award of the Mullard Medal of the Royal Society (with Prof Allen Hill FRS and Dr Monika Green), a Chemical Landmark Award from the Royal Society of Chemistry (with Allen Hill and Dr Graham Davis) and, along with his collaborator, Dr Joanne Santini (UCL), is a finalist in the 2017 BBSRC Innovator of the Year competition for their work on mediated enzyme sensors for the determination of arsenic in drinking water.

报告题目: Nucleic Acid Aptamers from Molecular Engineering to Bioanalytical Devices



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